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Article

Gene targeting in a nonhomologous end joining deficient Hypocrea jecorina.

Journal of biotechnology - 15 Jan 2009

Guangtao Zhang, Hartl Lukas, Schuster Andre, Polak Stefan, Schmoll Monika, Wang Tianhong, Seidl Verena, Seiboth Bernhard

Abstract excerpt

The industrially applied ascomycete Hypocrea jecorina (synonym: Trichoderma reesei) exhibits a low rate of exogenous DNA integration by homologous recombination (HR). This hinders the high-throughput generation of strains by gene replacement and is therefore impeding systematic functional gene analyses towards, e.g. strain improvement for protein or enzyme production. To increase the rate of HR events during...

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Identifiers

PMID: 19027803
DOI: 10.1016/j.jbiotec.2008.10.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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