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Article

Altered translational repression of an RNA-binding protein, Elav by AOA2-causative Senataxin mutation.

Synapse (New York, N.Y.) - 1 May 2017

Choudhury Saumitra Dey, Vs Ancy, Mushtaq Zeeshan, Kumar Vimlesh

Abstract excerpt

Mutations in Senataxin (SETX) gene causes two types of neurological disorders, Amyotrophic Lateral Sclerosis (ALS4) and Ataxia with Oculomotor Apraxia type 2 (AOA2). Recent studies in cultured cells suggest that SETX plays a crucial role at the interface of transcription and the DNA damage response. Whether SETX can alter translational of specific RNA is not known. In this study, we report that expressing...

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PMID: 28245518
DOI: 10.1002/syn.21969

Genes

SETX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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