Article
Comprehensive genomic profiling of relapsed and metastatic adenoid cystic carcinomas by next-generation sequencing reveals potential new routes to targeted therapies.
The American journal of surgical pathology - 1 Feb 2014
Ross Jeffrey S, Wang Kai, Rand Janna V, Sheehan Christine E, Jennings Timothy A, Al-Rohil Rami N, Otto Geoff A, Curran John C, Palmer Gary, Downing Sean R, Yelensky Roman, Lipson Doron, Balasubramanian Sohail, Garcia Lazaro, Mahoney Kristen, Ali Siraj M, Miller Vincent A, Stephens Philip J
Abstract excerpt
We hypothesized that next-generation sequencing could reveal actionable genomic alterations (GAs) and potentially expand treatment options for patients with advanced adenoid cystic carcinoma (ACC). Genomic profiling using next-generation sequencing was performed on hybridization-captured, adapter ligation libraries derived from 28 relapsed and metastatic formalin-fixed paraffin-embedded ACC. The 3230 exons of 182...
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