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Article

Molecular Profiling and the Impact of Treatment on Outcomes in Adenoid Cystic Carcinoma Type I and II.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2024

Hanna Glenn J, Grover Punita, Elliott Andrew, McGrath Julie, Xiu Joanne, Sukari Ammar, Johnson Jennifer M, Wise-Draper Trisha

Abstract excerpt

PURPOSE: Adenoid cystic carcinoma (ACC) is an uncommon salivary gland cancer with no approved therapies available to treat advanced, incurable disease. Recent molecular profiling efforts have identified two important subtypes: the more aggressive ACC-I is characterized by Notch pathway alterations and MYC amplification whereas ACC-II demonstrates a more indolent phenotype and TP63 overexpression. EXPERIMENTAL...

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Topics

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Share to B7-H1 Antigen
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Adenoid Cystic

Share to Gene Expression Regulation, Neoplastic

Share to Proto-Oncogene Proteins c-myc

Share to Receptor, Notch1

Share to Salivary Gland Neoplasms

Share to Tumor Microenvironment

Source

Identifiers

PMID: 38416410
DOI: 10.1158/1078-0432.CCR-23-3182

Genes

MYC
TP63
MYB
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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