Article
HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy.
Science (New York, N.Y.) - 27 Jan 1995
Coffin J M
Abstract excerpt
Several recent reports indicate that the long, clinically latent phase that characterizes human immunodeficiency virus (HIV) infection of humans is not a period of viral inactivity, but an active process in which cells are being infected and dying at a high rate and in large numbers. These results lead to a simple steady-state model in which infection, cell death, and cell replacement are in balance, and imply...
Topics
- Acquired Immunodeficiency Syndrome
- Antiviral Agents
- CD4 Lymphocyte Count
- CD4-Positive T-Lymphocytes
- Cell Death
- DNA, Viral
- Drug Resistance, Microbial
- Genetic Variation
- HIV
- HIV Infections
- Humans