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Article

Integrating genealogical and dynamical modelling to infer escape and reversion rates in HIV epitopes.

Proceedings. Biological sciences - 7 Jul 2013

Palmer Duncan, Frater John, Phillips Rodney, McLean Angela R, McVean Gil

Abstract excerpt

The rates of escape and reversion in response to selection pressure arising from the host immune system, notably the cytotoxic T-lymphocyte (CTL) response, are key factors determining the evolution of HIV. Existing methods for estimating these parameters from cross-sectional population data using ordinary differential equations (ODEs) ignore information about the genealogy of sampled HIV sequences, which has the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to gag Gene Products, Human Immunodeficiency Virus

Share to HIV Infections

Share to nef Gene Products, Human Immunodeficiency Virus

Share to pol Gene Products, Human Immunodeficiency Virus

Share to T-Lymphocytes, Cytotoxic

Source

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Identifiers

PMID: 23677344
DOI: 10.1098/rspb.2013.0696
PMCID: PMC3673055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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