Modelling the spread of HIV immune escape mutants in a vaccinated population.

doi:10.1371/journal.pcbi.1002289

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Modelling the spread of HIV immune escape mutants in a vaccinated population.

PLoS computational biology - 1 Dec 2011

Fryer Helen R, McLean Angela R

Abstract excerpt

Because cytotoxic T-lymphocytes (CTLs) have been shown to play a role in controlling human immunodeficiency virus (HIV) infection and because CTL-based simian immunodeficiency virus (SIV) vaccines have proved effective in non-human primates, one goal of HIV vaccine design is to elicit effective CTL responses in humans. Such a vaccine could improve viral control in patients who later become infected, thereby...

Topics

AIDS Vaccines
Computational Biology
Epidemics
Epitopes, T-Lymphocyte
HIV
HIV Infections
HLA Antigens
Host-Pathogen Interactions
Humans
Models, Immunological
Mutation
T-Lymphocytes, Cytotoxic

Source

Open in PubMed Open full text

Identifiers

PMID: 22144883
DOI: 10.1371/journal.pcbi.1002289
PMCID: PMC3228780

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics