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Article

Development of pyrosequencing methods for the rapid detection of RAS mutations in clinical samples.

Experimental and molecular pathology - 1 Oct 2015

Cortes Ulrich, Guilloteau Karline, Rouvreau Mélanie, Archaimbault Céline, Villalva Claire, Karayan-Tapon Lucie

Abstract excerpt

In advanced colorectal carcinoma (CRC) patients, extended RAS mutations testing (KRAS exons 2 to 4 and NRAS exons 2 to 4) is a prerequisite for patient stratification to anti-EGFr therapy. Accurately distinguishing mutant patients from potential responders has a clinically critical impact, and thus effective and low cost methods are needed for identification of the mutation status. We have developed quantitative...

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Source

Identifiers

PMID: 26163758
DOI: 10.1016/j.yexmp.2015.07.003

Genes

KRAS
NRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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