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Article

Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.

Cellular and molecular life sciences : CMLS - 1 Oct 2013

Wang Wei, Cai Jinyang, Wu Yingliang, Hu Li, Chen Zongyun, Hu Jun, Chen Ze, Li Wenxin, Guo Mingxiong, Huang Zan

Abstract excerpt

Previously, we found that two isoforms of the ZNF268 gene (ZNF268a and ZNF268b2, with and without the KRAB domain, respectively) might play distinct roles in normal epithelia and in cervical cancer. Here we further investigated that KRAB domain defined the function disparity in part by reinforcing nuclear localization of ZNF268a. We found that the A-box of KRAB alone retained major specific nuclear localization...

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Identifiers

PMID: 23665872
DOI: 10.1007/s00018-013-1359-4
PMCID: PMC11113806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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