Article
Zac1 functional interactions mediate AP-1 transcriptional activity.
Biochimica et biophysica acta - 1 Dec 2011
Wang Wei-Ming, Liu Shu-Ting, Huang Shih-Ming, Lin Wei-Shiang, Chen Shyi-Gen, Chang Yung-Lung
Abstract excerpt
A zinc-finger protein which regulates apoptosis and cell cycle arrest 1 (Zac1) is a novel seven-zinc-finger protein that can bind a specific GC-rich DNA element and has intrinsic transactivation activity; therefore, its role as a transcription factor has been proposed. Zac1 not only promotes cell cycle arrest and apoptosis but also acts as a transcriptional cofactor for nuclear receptors and p53. In this study,...
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