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Article

Parathyroid hormone-related protein is induced by hypoxia and promotes expression of the differentiated phenotype of human articular chondrocytes.

Clinical science (London, England : 1979) - 1 Nov 2013

Pelosi Michele, Lazzarano Stefano, Thoms Brendan L, Murphy Chris L

Abstract excerpt

PTHrP (parathyroid hormone-related protein) is crucial for normal cartilage development and long bone growth and acts to delay chondrocyte hypertrophy and terminal differentiation in the growth plate. After growth plate closure adult HACs (human articular chondrocytes) still produce PTHrP, suggesting a possible role for this factor in the permanent articular cartilage. However, the expression regulation and...

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Share to Basic Helix-Loop-Helix Transcription Factors
Share to Cartilage, Articular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Hypoxia

Share to Chondrocytes

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Share to Hypoxia-Inducible Factor 1, alpha Subunit

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Share to SOX9 Transcription Factor

Source

Identifiers

PMID: 23662774
DOI: 10.1042/CS20120610

Genes

SOX9
SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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