Article
The differentiation of prehypertrophic into hypertrophic chondrocytes drives an OA-remodeling program and IL-34 expression.
Osteoarthritis and cartilage - 1 Feb 2021
van Eegher S, Perez-Lozano M-L, Toillon I, Valour D, Pigenet A, Citadelle D, Bourrier C, Courtade-Gaïani S, Grégoire L, Cléret D, Malbos S, Nourissat G, Sautet A, Lafage-Proust M-H, Pastoureau P, Rolland-Valognes G, De Ceuninck F, Berenbaum F, Houard X
Abstract excerpt
OBJECTIVES: We hypothesize that chondrocytes from the deepest articular cartilage layer are pivotal in maintaining cartilage integrity and that the modification of their prehypertrophic phenotype to a hypertrophic phenotype will drive cartilage degradation in osteoarthritis. DESIGN: Murine immature articular chondrocytes (iMACs) were successively cultured into three different culture media to induce a progressive...
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