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Article

Hypoxia induces PTHrP gene transcription in human cancer cells through the HIF-2α

15 Sept 2010

Abstract excerpt

Parathyroid hormone-related protein (PTHrP) expressed by human cancer cells enhances tumor cell growth and metastasis in vivo and it is considered as the major factor responsible for humoral hypercalcemia of malignancy. Hypoxia is a widespread feature of most solid tumors. Here, we studied the effects of hypoxia on PTHrP expression. We found that PTHrP is transcriptionally induced by prolonged (48 h) hypoxia in...

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PMID: 20890122
DOI: 10.4161/cc.9.18.12931

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