Article

Promotion of chondrocyte-specific function by inhibition of HIF-targeting hydroxylases

2011-01-01

Abstract excerpt

Human articular cartilage is an avascular tissue, and therefore functions in a hypoxic environment. Cartilage cells, the chondrocytes, have adapted to this and actually use hypoxia to drive tissue-specific functions. Previous work in our laboratory has shown that human chondrocytes enhance cartilage matrix synthesis in response to hypoxia specifically through Hypoxia Inducible Factor 2alpha (HIF-2α) mediated upreg...

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Literature Corpus work: fbd1ddac-ab27-5fd5-8b9f-572de31114f0
DOI: 10.25560/7112

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