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Article

Genetic disruption of Abl nuclear import reduces renal apoptosis in a mouse model of cisplatin-induced nephrotoxicity.

Cell death and differentiation - 1 Jul 2013

Sridevi P, Nhiayi M K, Wang J Y J

Abstract excerpt

DNA damage activates nuclear Abl tyrosine kinase to stimulate intrinsic apoptosis in cancer cell lines and mouse embryonic stem cells. To examine the in vivo function of nuclear Abl in apoptosis, we generated Abl-μNLS (μ, mutated in nuclear localization signals) mice. We show here that cisplatin-induced apoptosis is defective in the renal proximal tubule cells (RPTC) from the Abl(μ/μ) mice. When injected with...

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Identifiers

PMID: 23660976
DOI: 10.1038/cdd.2013.42
PMCID: PMC3679464

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