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Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice.

Scientific reports - 10 Mar 2020

Uehara Masahiro, Kusaba Tetsuro, Ida Tomoharu, Nakai Kunihiro, Nakata Tomohiro, Tomita Aya, Watanabe-Uehara Noriko, Ikeda Kisho, Kitani Takashi, Yamashita Noriyuki, Kirita Yuhei, Matoba Satoaki, Humphreys Benjamin D, Tamagaki Keiichi

Abstract excerpt

The DNA damage response after kidney injury induces cell cycle arrest in renal tubular epithelial cells, resulting in the secretion of pro-fibrotic cytokines, thereby promoting interstitial fibrosis in a paracrine manner. Phosphorylation of ataxia-telangiectasia mutated (ATM) is the initial step in the DNA damage response and subsequent cell cycle arrest; however, the effects of ATM inhibition on the injured...

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PMID: 32157166
DOI: 10.1038/s41598-020-61456-7
PMCID: PMC7064514

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