Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage.

The American journal of pathology - 1 Nov 2004

Kawai Hanayo, Sato Waichi, Yuzawa Yukio, Kosugi Tomoki, Matsuo Seiichi, Takei Yoshifumi, Kadomatsu Kenji, Muramatsu Takashi

Abstract excerpt

Although cisplatin acts directly on proximal tubule epithelial cells and causes cell death, little is known regarding the biological significance of its secondary effects, such as inflammation. The growth factor midkine is highly expressed in the proximal tubule and exerts ambivalent activities as to cisplatin nephrotoxicity, ie, anti-apoptotic and chemotactic ones. Here we report that midkine-deficient mice show...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Urea Nitrogen
Share to Blotting, Northern

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cisplatin

Share to Enzyme-Linked Immunosorbent Assay

Share to In Situ Nick-End Labeling

Share to Neutrophils

Share to Oligonucleotides, Antisense

Share to Ribonucleases

Source

Open in PubMed Open full text

Identifiers

PMID: 15509530
DOI: 10.1016/S0002-9440(10)63417-7
PMCID: PMC1618674

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage.PMID 15509530Read ↗

ELMO1 dependent efferocytosis protects from nephrotoxin induced acute kidney injurySemantic proximity Read ↗

TCR+CD4-CD8- (double negative) T cells protect from cisplatin-induced renal epithelial cell apoptosis and acute kidney injury.Semantic proximity Read ↗

Cell cycle arrest in a model of colistin nephrotoxicitySemantic proximity Read ↗

The leukotriene B4-leukotriene B4 receptor axis promotes cisplatin-induced acute kidney injury by modulating neutrophil recruitment.Semantic proximity Read ↗

Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice.Semantic proximity Read ↗

MiR-30c regulates cisplatin-induced apoptosis of renal tubular epithelial cells by targeting Bnip3L and Hspa5Semantic proximity Read ↗

Basement membrane protein nidogen-1 is a target of meprin β in cisplatin nephrotoxicity.Semantic proximity Read ↗

Assessment of Gentamicin and Cisplatin-Induced Kidney Damage Mediated via Necrotic and Apoptosis Genes in Albino RatsSemantic proximity Read ↗

MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidneySemantic proximity Read ↗

Tumor Necrosis Factor-α Induces Intrinsic Apoptotic Signaling During Renal Obstruction Through Truncated Bid ActivationSemantic proximity Read ↗

TIM2 gene deletion results in susceptibility to cisplatin-induced kidney toxicity.Semantic proximity Read ↗

MIF-2/D-DT enhances proximal tubular cell regeneration through SLPI- and ATF4-dependent mechanisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.