Article
Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity.
Clinical and translational science - 1 Sept 2017
Hu S, Leblanc A F, Gibson A A, Hong K W, Kim J Y, Janke L J, Li L, Vasilyeva A, Finkelstein D B, Sprowl J A, Sweet D H, Schlatter E, Ciarimboli G, Schellens Jhm, Baker S D, Pabla N, Sparreboom A
Abstract excerpt
Cisplatin is among the most widely used anticancer drugs and known to cause a dose-limiting nephrotoxicity, which is partially dependent on the renal uptake carrier OCT2. We here report a previously unrecognized, OCT2-independent pathway of cisplatin-induced renal injury that is mediated by the organic anion transporters OAT1 and OAT3. Using transporter-deficient mouse models, we found that this mechanism...
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