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Article

Live-cell imaging of actin dynamics reveals mechanisms of stereocilia length regulation in the inner ear.

Nature communications - 21 Apr 2015

Drummond Meghan C, Barzik Melanie, Bird Jonathan E, Zhang Duan-Sun, Lechene Claude P, Corey David P, Cunningham Lisa L, Friedman Thomas B

Abstract excerpt

The maintenance of sensory hair cell stereocilia is critical for lifelong hearing; however, mechanisms of structural homeostasis remain poorly understood. Conflicting models propose that stereocilia F-actin cores are either continually renewed every 24-48 h via a treadmill or are stable, exceptionally long-lived structures. Here to distinguish between these models, we perform an unbiased survey of stereocilia...

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Identifiers

PMID: 25898120
DOI: 10.1038/ncomms7873
PMCID: PMC4411292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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