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Article

The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and stereocilia development.

Cell motility and the cytoskeleton - 1 Jul 2007

Mogensen Mette M, Rzadzinska Agnieszka, Steel Karen P

Abstract excerpt

Stereocilia, finger-like projections forming the hair bundle on the apical surface of sensory hair cells in the cochlea, are responsible for mechanosensation and ultimately the perception of sound. The actin cytoskeleton of the stereocilia contains hundreds of tightly cross-linked parallel actin filaments in a paracrystalline array and it is vital for their function. Although several genes have been identified...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17326148
DOI: 10.1002/cm.20199
PMCID: PMC2682331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and stereocilia development.PMID 17326148Read ↗

Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31.Semantic proximity Read ↗

Elongation of hair cell stereocilia is defective in the mouse mutant whirler.Semantic proximity Read ↗

Mutant analysis reveals whirlin as a dynamic organizer in the growing hair cell stereocilium.Semantic proximity Read ↗

A novel stereocilia defect in sensory hair cells of the deaf mouse mutant Tasmanian devil.Semantic proximity Read ↗

Gene Therapy Restores Hair Cell Stereocilia Morphology in Inner Ears of Deaf Whirler MiceSemantic proximity Read ↗

Twinfilin 2 regulates actin filament lengths in cochlear stereocilia.Semantic proximity Read ↗

β-Actin and fascin-2 cooperate to maintain stereocilia length.Semantic proximity Read ↗

CIB2 function is distinct from Whirlin in the development of cochlear stereocilia staircase patternSemantic proximity Read ↗

Whirlin complexes with p55 at the stereocilia tip during hair cell development.Semantic proximity Read ↗

Mutations of the mouse ELMO domain containing 1 gene (Elmod1) link small GTPase signaling to actin cytoskeleton dynamics in hair cell stereocilia.Semantic proximity Read ↗

CIB2 function is distinct from that of whirlin in the organization of sterocilia architecture.Semantic proximity Read ↗

Alternative Splice Forms Influence Functions of Whirlin in Mechanosensory Hair Cell Stereocilia.Semantic proximity Read ↗

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