Article

CIB2 function is distinct from Whirlin in the development of cochlear stereocilia staircase pattern

2024-07-31

Abstract excerpt

<h4>Summary</h4> Variations in genes coding for calcium and integrin binding protein 2 (CIB2) and whirlin cause deafness both in humans and mice. We previously reported that CIB2 binds to whirlin, and is essential for normal staircase architecture of auditory hair cells stereocilia. Here, we refine the interacting domains between these proteins and provide evidence that both proteins have distinct role in the dev...

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Literature Corpus work: 89639c45-84ed-51eb-a174-7b189f7de2bf
DOI: 10.1101/2024.07.30.605852

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