Article
A novel stereocilia defect in sensory hair cells of the deaf mouse mutant Tasmanian devil.
The European journal of neuroscience - 1 Oct 2002
Erven Alexandra, Skynner Michael J, Okumura Katsuzumi, Takebayashi Shin-ichiro, Brown Steve D M, Steel Karen P, Allen Nicholas D
Abstract excerpt
Stereocilia are specialized actin-filled, finger-like processes arrayed in rows of graded heights to form a crescent or W-shape on the apical surface of sensory hair cells. The stereocilia are deflected by the vibration of sound, which opens transduction channels and allows an influx of ions to depolarize the hair cell, in turn triggering synaptic activity. The specialized morphology and organization of the...
Topics
- Action Potentials
- Animals
- Animals, Newborn
- Cilia
- Cochlear Nerve
- Deafness
- Hair Cells, Auditory
- Hearing
- Mice
- Mice, Mutant Strains
- Mice, Transgenic
- Microscopy, Electron
- Microscopy, Electron, Scanning
- Mutation