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<i>PALB2</i> Mutations and Breast-Cancer Risk

6 Aug 2014

Abstract excerpt

The response to and repair of DNA damage are central to our understanding of the causes of breast cancer. DNA damage results from environmental exposure to genotoxic agents, lifestyle factors, and cellular metabolism. Among the most lethal forms of DNA damage are double-strand breaks. A failure to accurately repair double-strand breaks has catastrophic consequences for the cell, including aneuploidy and genomic...

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PMID: 25099582
DOI: 10.1056/nejme1405784

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