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Article

Molecular analysis of PALB2-associated breast cancers.

The Journal of pathology - 1 May 2018

Lee Jue Er Amanda, Li Na, Rowley Simone M, Cheasley Dane, Zethoven Magnus, McInerny Simone, Gorringe Kylie L, James Paul A, Campbell Ian G

Abstract excerpt

PALB2 is established as the most clinically important moderate to high penetrance breast cancer predisposition gene after BRCA1 and BRCA2. Mutations in classical familial cancer predisposition genes are presumed to be recessive at the cellular level and therefore a second inactivating somatic mutation is required in the tumour tissue. However, from the limited data that exist, PALB2 may be an example of a cancer...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29431189
DOI: 10.1002/path.5055

Genes

PALB2
BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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