Article
Loss of the tumor suppressor PML in human cancers of multiple histologic origins.
Journal of the National Cancer Institute - 18 Feb 2004
Gurrieri Carmela, Capodieci Paola, Bernardi Rosa, Scaglioni Pier Paolo, Nafa Khedoudja, Rush Laura J, Verbel David A, Cordon-Cardo Carlos, Pandolfi Pier Paolo
Abstract excerpt
BACKGROUND: The PML gene is fused to the RARalpha gene in the vast majority of acute promyelocytic leukemias (APL) and has been implicated in the control of key tumor-suppressive pathways. However, its role in the pathogenesis of human cancers other than APL is still unclear. We therefore assessed the status and expression of the PML gene in solid tumors of multiple histologic origins. METHODS: We created tumor...
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