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Article

Loss of the tumor suppressor PML in human cancers of multiple histologic origins.

Journal of the National Cancer Institute - 18 Feb 2004

Gurrieri Carmela, Capodieci Paola, Bernardi Rosa, Scaglioni Pier Paolo, Nafa Khedoudja, Rush Laura J, Verbel David A, Cordon-Cardo Carlos, Pandolfi Pier Paolo

Abstract excerpt

BACKGROUND: The PML gene is fused to the RARalpha gene in the vast majority of acute promyelocytic leukemias (APL) and has been implicated in the control of key tumor-suppressive pathways. However, its role in the pathogenesis of human cancers other than APL is still unclear. We therefore assesse...

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Source

Identifiers

PMID: 14970276
DOI: 10.1093/jnci/djh043

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14970276-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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