Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ppm1d truncating mutations promote the development of genotoxic stress-induced AML.

Leukemia - 1 Nov 2023

Burocziova Monika, Danek Petr, Oravetzova Anna, Chalupova Zuzana, Alberich-Jorda Meritxell, Macurek Libor

Abstract excerpt

Hematopoietic stem cells (HSCs) ensure blood cell production during the life-time of an organism, and to do so they need to balance self-renewal, proliferation, differentiation, and migration in a steady state as well as in response to stress or injury. Importantly, aberrant proliferation of HSCs leads to hematological malignancies, and thus, tight regulation by various tumor suppressor pathways, including p53,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to DNA Damage
Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 37709843
DOI: 10.1038/s41375-023-02030-8
PMCID: PMC10624630

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ppm1d truncating mutations promote the development of genotoxic stress-induced AML.PMID 37709843Read ↗

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.Semantic proximity Read ↗

PPM1D in Solid and Hematologic Malignancies: Friend and Foe?Semantic proximity Read ↗

PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic ChemotherapySemantic proximity Read ↗

Protein phosphatase, Mg2+/Mn2+-dependent 1D (PPM1D) mutations in haematological cancer.Semantic proximity Read ↗

Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon.Semantic proximity Read ↗

Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.Semantic proximity Read ↗

SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells.Semantic proximity Read ↗

Spectrum, prevalence, and clinical correlates of PPM1D mutations in patients with clonal hematopoiesis and clonal cytopenias.Semantic proximity Read ↗

The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in MiceSemantic proximity Read ↗

<i>SOD1</i> is a synthetic lethal target in <i>PPM1D</i> -mutant leukemia cellsSemantic proximity Read ↗

Delayed Trp53 activation protects Dnmt3a-mutant hematopoietic stem cells from inflammatory attrition.Semantic proximity Read ↗

PPM1D430, a novel alternative splicing variant of the human PPM1D, can dephosphorylate p53 and exhibits specific tissue expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.