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Article

Interlinked fast and slow positive feedback loops drive reliable cell decisions.

Science (New York, N.Y.) - 21 Oct 2005

Brandman Onn, Ferrell James E, Li Rong, Meyer Tobias

Abstract excerpt

Positive feedback is a ubiquitous signal transduction motif that allows systems to convert graded inputs into decisive, all-or-none outputs. Here we investigate why the positive feedback switches that regulate polarization of budding yeast, calcium signaling, Xenopus oocyte maturation, and various other processes use multiple interlinked loops rather than single positive feedback loops. Mathematical simulations...

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Identifiers

PMID: 16239477
DOI: 10.1126/science.1113834
PMCID: PMC3175767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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