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Article

A tractable physical model for the yeast polarity predicts epistasis and fitness.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 22 May 2023

Daalman Werner Karl-Gustav, Sweep Els, Laan Liedewij

Abstract excerpt

Accurate phenotype prediction based on genetic information has numerous societal applications, such as crop design or cellular factories. Epistasis, when biological components interact, complicates modelling phenotypes from genotypes. Here we show an approach to mitigate this complication for polarity establishment in budding yeast, where mechanistic information is abundant. We coarse-grain molecular interactions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37004720
DOI: 10.1098/rstb.2022.0044
PMCID: PMC10067261

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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