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Article

Identification of amphiphysin 1 as an endogenous substrate for CDKL5, a protein kinase associated with X-linked neurodevelopmental disorder.

Archives of biochemistry and biophysics - 15 Jul 2013

Sekiguchi Mari, Katayama Syouichi, Hatano Naoya, Shigeri Yasushi, Sueyoshi Noriyuki, Kameshita Isamu

Abstract excerpt

Cyclin-dependent kinase-like 5 (CDKL5) is a Ser/Thr protein kinase predominantly expressed in brain and mutations of its gene are known to be associated with neurodevelopmental disorders such as X-linked West syndrome and Rett syndrome. However, the physiological substrates of CDKL5 that are directly linked to these neurodevelopmental disorders are currently unknown. In this study, we explored endogenous...

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Source

Identifiers

PMID: 23651931
DOI: 10.1016/j.abb.2013.04.012

Genes

CDKL5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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