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Article

Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11α.

Journal of neurochemistry - 1 Sept 2012

Park Jung-Hwa, Jung Min-Su, Kim Yeun-Soo, Song Woo-Joo, Chung Sul-Hee

Abstract excerpt

Dual-specificity tyrosine(Y)-phosphorylation-regulated kinase 1A (Dyrk1A) is a protein kinase that might be responsible for mental retardation and early onset of Alzheimer's disease in Down's syndrome patients. Dyrk1A plays a role in many cellular pathways through phosphorylation of diverse substrate proteins; however, its role in synaptic vesicle exocytosis is poorly understood. Munc18-1, a central regulator of...

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Identifiers

PMID: 22765017
DOI: 10.1111/j.1471-4159.2012.07861.x

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Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11α.PMID 22765017Read ↗

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