Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase.

Proceedings of the National Academy of Sciences of the United States of America - 7 Dec 1999

Huang D, Patrick G, Moffat J, Tsai L H, Andrews B

Abstract excerpt

Mammalian Cdk5 is a member of the cyclin-dependent kinase family that is activated by a neuron-specific regulator, p35, to regulate neuronal migration and neurite outgrowth. p35/Cdk5 kinase colocalizes with and regulates the activity of the Pak1 kinase in neuronal growth cones and likely impacts on actin cytoskeletal dynamics through Pak1. Here, we describe a functional homologue of Cdk5 in budding yeast, Pho85....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to COS Cells
Share to Cyclin-Dependent Kinase 5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinases

Share to Cytoskeleton

Share to Enzyme Activation

Share to G1 Phase

Share to Insecta

Source

Open in PubMed Open full text

Identifiers

PMID: 10588725
DOI: 10.1073/pnas.96.25.14445
PMCID: PMC24456

Genes

CDK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase.PMID 10588725Read ↗

CDK5: A Unique CDK and Its Multiple Roles in the Nervous SystemSemantic proximity Read ↗

Mouse cyclin-dependent kinase (Cdk) 5 is a functional homologue of a yeast Cdk, pho85 kinase.Semantic proximity Read ↗

A systematic high-throughput screen of a yeast deletion collection for mutants defective in PHO5 regulation.Semantic proximity Read ↗

The Structural Perspective on CDK5Semantic proximity Read ↗

Physiological and Pathological Roles of Cdk5: Potential Directions for Therapeutic Targeting in Neurodegenerative DiseaseSemantic proximity Read ↗

A kinase of many talents: non-neuronal functions of CDK5 in development and diseaseSemantic proximity Read ↗

Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan.Semantic proximity Read ↗

Identification and characterization of a novel phosphoregulatory site on cyclin-dependent kinase 5.Semantic proximity Read ↗

Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice.Semantic proximity Read ↗

From Plk1 to Plk5Semantic proximity Read ↗

Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder.Semantic proximity Read ↗

CDK5: an oncogene or an anti-oncogene: location location locationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.