Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers.

The Journal of pharmacy and pharmacology - 1 Jun 2013

Yasar Umit, Greenblatt David J, Guillemette Chantal, Court Michael H

Abstract excerpt

OBJECTIVES: Interindividual variability in glucuronidation of bilirubin and drugs by UDP-glucuronosyltransferase 1A1 (UGT1A1) is considerable and only partially explained by genetic polymorphisms and enzyme inducers. Here we determined whether a well-known epigenetic modification, cytosine methylation, explains a proportion of this variability in human liver. METHODS: UGT1A1 phenotypes, including UGT1A1 protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bilirubin
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytosine

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Glucuronosyltransferase

Share to Microsomes, Liver

Source

Open in PubMed Open full text

Identifiers

PMID: 23647681
DOI: 10.1111/jphp.12053
PMCID: PMC6195312

Genes

UGT1A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers.PMID 23647681Read ↗

Epigenetics and microRNAs in UGT1AsSemantic proximity Read ↗

Family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A): from Gilbert's syndrome to genetic organization and variability.Semantic proximity Read ↗

Genetic factors affecting gene transcription and catalytic activity of UDP-glucuronosyltransferases in human liver.Semantic proximity Read ↗

Analysis of DNA methylation landscape reveals the roles of DNA methylation in the regulation of drug metabolizing enzymesSemantic proximity Read ↗

Variability and function of family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A).Semantic proximity Read ↗

The Impact of UGT1A1 Genetic Variability on Enzyme Expression in Liver Pathology.Semantic proximity Read ↗

UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5'-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation.Semantic proximity Read ↗

Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups.Semantic proximity Read ↗

Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers.Semantic proximity Read ↗

Functions and transcriptional regulation of adult human hepatic UDP-glucuronosyl-transferases (UGTs): mechanisms responsible for interindividual variation of UGT levels.Semantic proximity Read ↗

Epigenome-Wide Association Study Identifies Methylation Sites Associated With Liver Enzymes and Hepatic Steatosis.Semantic proximity Read ↗

Histone acetylation at the sulfotransferase 1a1 gene is associated with its hepatic expression in normal agingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.