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Epigenome-Wide Association Study Identifies Methylation Sites Associated With Liver Enzymes and Hepatic Steatosis.

Gastroenterology - 1 Oct 2017

Nano Jana, Ghanbari Mohsen, Wang Wenshi, de Vries Paul S, Dhana Klodian, Muka Taulant, Uitterlinden André G, van Meurs Joyce B J, Hofman Albert, Franco Oscar H, Pan Qiuwei, Murad Sarwa Darwish, Dehghan Abbas

Abstract excerpt

BACKGROUND & AIMS: Epigenetic mechanisms might be involved in the regulation of liver enzyme level. We aimed to identify CpG sites at which DNA methylation levels are associated with blood levels of liver enzymes and hepatic steatosis. METHODS: We conducted an epigenome-wide association study in whole blood for liver enzyme levels, including gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), and...

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PMID: 28624579
DOI: 10.1053/j.gastro.2017.06.003

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PHGDH

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