Article

Histone acetylation at the sulfotransferase 1a1 gene is associated with its hepatic expression in normal aging

2020-09-18

Abstract excerpt

Phase II drug metabolism is poorly studied in advanced age and older adults may exhibit significant variability in their expression of phase II enzymes. We hypothesized that age-related changes to epigenetic regulation of genes involved in phase II drug metabolism may contribute to these effects. We examined published epigenome-wide studies of human blood and identified the SULT1A1 and UGT1A6 genes as the top lo...

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Literature Corpus work: e2946e29-6abb-54e3-9ef1-b5680a33f90b
DOI: 10.1101/2020.09.17.300657

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