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Article

The Impact of UGT1A1 Genetic Variability on Enzyme Expression in Liver Pathology.

Genes - 21 May 2026

Szeląg-Pieniek Sylwia, Kucak Joanna, Malinowski Damian, Oswald Stefan, Droździk Marek, Kurzawski Mateusz

Abstract excerpt

BACKGROUND: Glucuronidation is a major phase II biotransformation reaction responsible for the inactivation and elimination of endogenous compounds and pharmaceuticals. This process is catalyzed by enzymes belonging to the UDP-glucuronosyltransferase (UGT) family, among which UGT1A1 is the most extensively studied. UGT1A1 plays a critical role in the metabolism of numerous drugs and is essential for bilirubin...

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Identifiers

PMID: 42195046
DOI: 10.3390/genes17050589
PMCID: PMC13205437

Genes

UGT1A1
ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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