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Article

Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers.

The pharmacogenomics journal - 1 Jun 2009

Ghotbi Roza, Gomez Alvin, Milani Lili, Tybring Gunnel, Syvänen Ann-Christine, Bertilsson Leif, Ingelman-Sundberg Magnus, Aklillu Eleni

Abstract excerpt

The basis for interindividual variation in the CYP1A2 gene expression is not fully understood and the known genetic polymorphisms in the gene provide no explanation. We investigated whether the CYP1A2 gene expression is regulated by DNA methylation and displays allele-specific expression (ASE) using 65 human livers. Forty-eight percent of the livers displayed ASE not associated to the CYP1A2 mRNA levels. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19274061
DOI: 10.1038/tpj.2009.4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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