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Article

Mechanisms of Resistance to the Toxicity of Cyclophosphamide

1 Aug 1999

Abstract excerpt

Resistance to cyclophosphamide therapy continues to be a major reason for treatment failure. This chapter covers some of the mechanisms implicated in resistance to the toxic and mutagenic effects of cyclophosphamide therapy in the laboratory and clinic. Since resistance is likely to be the result of a number of interrelating factors, this chapter evaluates the contribution of both glutathione and DNA repair...

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PMID: 10469893
DOI: 10.2174/1381612805666230110214938

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