Article
Age-, tissue-, and Ah genotype-dependent differences in the binding of 3-methylcholanthrene and its metabolite(s) to mouse DNA.
Cancer research - 15 Jul 1990
Lu L J, Harvey R G, Lee H, Baxter J R, Anderson L M
Abstract excerpt
The induction of transplacental carcinogenesis by 3-methylcholanthrene (MC) in mice is determined, in part, by the genotype at the Ah locus. The relationship of Ah genotype and MC-induced DNA adducts was tested by comparing the response of pregnant and fetal C57BL/6 mice (Ahb Ahb; responsive to t...
Topics
- Animals
- Autoradiography
- Biotransformation
- DNA
- Female
- Fetus
- Genotype
- Methylcholanthrene
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Organ Specificity
- Phosphorus Radioisotopes
- Placenta
- Pregnancy