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Article

Genetic variation in the metabolism of coumarin in mouse liver.

Pharmacogenetics - 1 Apr 1999

Lovell D P, van Iersel M, Walters D G, Price R J, Lake B G

Abstract excerpt

The metabolism of 50 microM [3-14C] coumarin to polar products separated by high performance liquid chromatography (HPLC) and covalently bound metabolites in liver microsomes was compared in a series of inbred strains of mice. Coumarin metabolism to total polar products was higher in female than male mice. In all strains, the coumarin 3,4-epoxidation pathway was the major route of metabolism with...

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Source

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PMID: 10376771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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