Article
Cytochrome P4501A1 and 1A2 gene expression in the liver of 3-methylcholanthrene- and o-aminoazotoluene-treated mice: a comparison between PAH-responsive and PAH-nonresponsive strains.
Toxicological sciences : an official journal of the Society of Toxicology - 1 May 2003
Zacharova Ludmila Yu, Gulyaeva Ludmila F, Lyakhovich Vyacheslav V, Mikhailova Olga N, Timofeeva Olga A, Filipenko Maxim L, Kaledin Vasily I
Abstract excerpt
The objective of this study was to investigate cytochrome P4501A1 and 1A2 mRNA, protein, and enzyme activity in the liver of male mice differing in the aryl hydrocarbon receptor (AhR) genotype during treatment with the carcinogenic compounds 3-methylcholanthrene (MC) and o-aminoazotoluene (OAT). The basal levels of the CYP1A1 and CYP1A2 enzyme activities were comparable among the mouse strains examined....
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