Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prenatal exposure of mice to the human liver carcinogen aflatoxin B1 reveals a critical window of susceptibility to genetic change.

International journal of cancer - 15 Mar 2015

Chawanthayatham Supawadee, Thiantanawat Apinya, Egner Patricia A, Groopman John D, Wogan Gerald N, Croy Robert G, Essigmann John M

Abstract excerpt

It has become axiomatic that critical windows of susceptibility to genotoxins exist and that genetic damage in utero may be a trigger for later life cancers. Data supporting this critical window hypothesis are remarkably few. This study provides a quantitative bridge between DNA damage by the liver carcinogen aflatoxin B1 (AFB1 ) during prenatal development and the risk of later life genetic disease. AFB1 was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aflatoxin B1
Share to Carcinogens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to DNA Adducts

Share to Mice, Inbred C57BL

Source

Open in PubMed Open full text

Identifiers

PMID: 25070670
DOI: 10.1002/ijc.29102
PMCID: PMC4289428

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prenatal exposure of mice to the human liver carcinogen aflatoxin B1 reveals a critical window of susceptibility to genetic change.PMID 25070670Read ↗

Early Life Exposure to Aflatoxin B1 in Rats: Alterations in Lipids, Hormones, and DNA Methylation among the OffspringSemantic proximity Read ↗

Mutational spectra of aflatoxin B1 in vivo establish biomarkers of exposure for human hepatocellular carcinoma.Semantic proximity Read ↗

Exposure to aflatoxin B <sub>1</sub> <i>in utero</i> is associated with DNA methylation in white blood cells of infants in The GambiaSemantic proximity Read ↗

Molecular biomarkers for aflatoxins: from adducts to gene mutations to human liver cancer.Semantic proximity Read ↗

High susceptibility of neonatal mice to molecular, biochemical and cytogenetic alterations induced by environmental cigarette smoke and light.Semantic proximity Read ↗

In utero Exposure to Genotoxicants Leading to Genetic Mosaicism: An Overlooked Window of Susceptibility in Genetic Toxicology Testing?Semantic proximity Read ↗

Environmental genotoxicants/carcinogens and childhood cancer: bridgeable gaps in scientific knowledge.Semantic proximity Read ↗

Critical windows of exposure for children's health: cancer in human epidemiological studies and neoplasms in experimental animal models.Semantic proximity Read ↗

Structurally Similar Mycotoxins Aflatoxin B1 and Sterigmatocystin Trigger Different and Distinctive High-Resolution Mutational Spectra in Mammalian Cells.Semantic proximity Read ↗

The Distinct Roles of NEIL1 and XPA in Limiting Aflatoxin B1-Induced Mutagenesis in Mice.Semantic proximity Read ↗

Differential effect of gestation stage on benzo(a)pyrene-induced micronucleus formation and/or covalent DNA modifications in mice.Semantic proximity Read ↗

An overview on possible links between aflatoxin B1 exposure and gallbladder cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.