Article
Oxidative DNA damage in liver of mice with different susceptibility to hepatocarcinogenesis.
Roczniki Akademii Medycznej w Bialymstoku (1995) - 1 Jan 2000
Sipowicz M A, Anderson L M, Kasprzak K S
Abstract excerpt
Susceptibility to spontaneous or chemically-induced liver tumors in mice has been demonstrated to be strain dependent, with the tumor development or promotion phase contributing most to variability. Since reactive oxygen species are thought to play a role in carcinogenesis, especially tumor promotion, we investigated steady-state levels of 8-hydroxy-2'-deoxyguanosine (8-oxo-dG) in hepatic DNA from age matched (7...
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