Article
Differences in the response to oxidative stress and mutant frequency in CD (Sprague-Dawley) and Fisher 344 rats due to an induced inflammatory response.
Environmental and molecular mutagenesis - 1 Jan 2000
Sams R, Blaydes B, Warbritton A, Lomax L G, Bucci T, Delclos K B
Abstract excerpt
In this study, the rodent air pouch model was used to examine the production and processing of oxidative DNA damage in two strains of rats commonly used in toxicity testing. An inflammatory response was induced by injecting zymosan A (50 mg) into an air pouch on male CD (Sprague-Dawley [S-D]) and Fisher 344 (F-344) rats, and the animals were then sacrificed at 1, 3, 7, 14, and 28 days (n = 6 per time point per...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.