Article
Fetal mouse susceptibility to transplacental carcinogenesis: differential influence of Ah receptor phenotype on effects of 3-methylcholanthrene, 12-dimethylbenz[a]anthracene, and benzo[a]pyrene.
Pharmacogenetics - 1 Dec 1995
Anderson L M, Ruskie S, Carter J, Pittinger S, Kovatch R M, Riggs C W
Abstract excerpt
Genetic backcrosses of C57BL/6 and DBA/2 mice were used to examine the influence of maternal and fetal polymorphisms at the Ahr locus on susceptibility to transplacental carcinogenesis by 3-methylcholanthrene, 7,12-dimethylbenz[a]anthracene, and benzo[a]pyrene. (C57BL/6 x DBA/2) F1 mothers were b...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- Benzo(a)pyrene
- Carcinogens
- Crosses, Genetic
- Female
- Liver Neoplasms, Experimental
- Lung Neoplasms
- Male
- Maternal-Fetal Exchange
- Methylcholanthrene
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Pharmacogenetics