Role of the maternal environment in determining susceptibility to transplacentally induced chemical carcinogenesis in mouse fetuses.

doi:10.1093/carcin/11.11.1979

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Role of the maternal environment in determining susceptibility to transplacentally induced chemical carcinogenesis in mouse fetuses.

Carcinogenesis - 1 Nov 1990

Miller M S, Jones A B, Chauhan D P, Anderson L M

Abstract excerpt

Treatment of pregnant mice with 3-methylcholanthrene (MC) causes lung and liver tumors in the offspring, the incidences of which are greatly influenced by the Ah locus regulated induction phenotype for aryl hydrocarbon hydroxylase activity (AHH) in both the mother and fetuses. In order to examine the biochemical and molecular mechanisms responsible for the modulating effect of maternal environment on tumor...

Topics

Animals
Aryl Hydrocarbon Hydroxylases
Crosses, Genetic
Cytochrome P-450 Enzyme System
Disease Susceptibility
Enzyme Induction
Female
Fetus
Gene Expression Regulation, Neoplastic
Liver
Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Maternal-Fetal Exchange

Methylcholanthrene

Mice

Mothers

Phenotype

Pregnancy

RNA

Source

Open in PubMed

Identifiers

PMID: 1699680
DOI: 10.1093/carcin/11.11.1979

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1699680-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Role of the maternal environment in determining susceptibility to transplacentally induced chemical carcinogenesis in mouse fetuses.PMID 1699680Read ↗

Fetal mouse susceptibility to transplacental carcinogenesis: differential influence of Ah receptor phenotype on effects of 3-methylcholanthrene, 12-dimethylbenz[a]anthracene, and benzo[a]pyrene.Semantic proximity Read ↗

Age-, tissue-, and Ah genotype-dependent differences in the binding of 3-methylcholanthrene and its metabolite(s) to mouse DNA.Semantic proximity Read ↗

Long-term (imprinting) effects of transplacental treatment of mice with 3-methylcholanthrene or beta-naphthoflavone on hepatic metabolism of 3-methylcholanthrene.Semantic proximity Read ↗

The murine Cyp1a1 gene is expressed in a restricted spatial and temporal pattern during embryonic development.Semantic proximity Read ↗

Coordinated maternal imprinting and paternal genotype determined the ultimate level of hepatic cytochrome P-450 and associated monooxygenase activities.Semantic proximity Read ↗

In utero exposure of rats to high-fat diets perturbs gene expression profiles and cancer susceptibility of prepubertal mammary glands.Semantic proximity Read ↗

In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling.Semantic proximity Read ↗

Inheritance of pulmonary adenoma susceptibility in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.