Article
Reversal of the multidrug resistance phenotype with cremophor EL, a common vehicle for water-insoluble vitamins and drugs.
Cancer research - 15 Jul 1990
Woodcock D M, Jefferson S, Linsenmeyer M E, Crowther P J, Chojnowski G M, Williams B, Bertoncello I
Abstract excerpt
A polyethoxylated castor oil, Cremophor EL, which is used as a vehicle for p.o. and i.v. administration of water-insoluble compounds in humans, can reverse the multidrug resistance (MDR) phenotype at doses which are likely to be readily achievable clinically. Using flow cytofluorometric analysis...
Topics
- Animals
- Cell Division
- Cell Line
- Colony-Forming Units Assay
- Daunorubicin
- Drug Carriers
- Drug Resistance
- Gene Expression
- Growth Substances
- Hematopoietic Stem Cells
- Humans
- Kinetics
- Mice
- Mice, Inbred C57BL
- Phenotype
- Polyethylene Glycols
- Solvents
- Vinblastine