Paclitaxel-induced cytotoxicity--the effects of cremophor EL (castor oil) on two human breast cancer cell lines with acquired multidrug resistant phenotype and induced expression of the permeability glycoprotein.

doi:10.1016/0959-8049(94)90546-0

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Article

Paclitaxel-induced cytotoxicity--the effects of cremophor EL (castor oil) on two human breast cancer cell lines with acquired multidrug resistant phenotype and induced expression of the permeability glycoprotein.

European journal of cancer (Oxford, England : 1990) - 1 Jan 1994

Fjällskog M L, Frii L, Bergh J

Abstract excerpt

Paclitaxel (Taxol) is a new cytotoxic agent with considerable activity in phase II studies on metastatic breast cancer. Paclitaxel for clinical use is dissolved in the solvents cremophor EL and ethanol. In this study, we added paclitaxel, formulated either in cremophor EL and ethanol or only in e...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Breast Neoplasms
Carrier Proteins
Cell Survival
Dose-Response Relationship, Drug
Doxorubicin
Drug Resistance
Drug Screening Assays, Antitumor
Drug Synergism
Ethanol
Female
Glycerol
Humans
Membrane Glycoproteins

Source

Open in PubMed

Identifiers

PMID: 7915908
DOI: 10.1016/0959-8049(94)90546-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7915908-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Neoplasm Proteins

Paclitaxel

Phenotype

Solvents