Article
Disposition of Cremophor EL in humans limits the potential for modulation of the multidrug resistance phenotype in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 1998
Sparreboom A, Verweij J, van der Burg M E, Loos W J, Brouwer E, Viganò L, Locatelli A, de Vos A I, Nooter K, Stoter G, Gianni L
Abstract excerpt
The purpose of the present study was to characterize the distribution and elimination kinetics of the paclitaxel vehicle Cremophor EL (CrEL), a polyoxyethylated castor oil that can modulate P-glycoprotein-mediated multidrug resistance in vitro. The pharmacokinetics of CrEL were studied using noncompartmental models in 23 patients with histological proof of malignant solid tumors, receiving paclitaxel as a 3-h...
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