Measurement of cremophor EL following taxol: plasma levels sufficient to reverse drug exclusion mediated by the multidrug-resistant phenotype.

doi:10.1093/jnci/85.20.1685

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Article

Measurement of cremophor EL following taxol: plasma levels sufficient to reverse drug exclusion mediated by the multidrug-resistant phenotype.

Journal of the National Cancer Institute - 20 Oct 1993

Webster L, Linsenmeyer M, Millward M, Morton C, Bishop J, Woodcock D

Abstract excerpt

BACKGROUND: Paclitaxel (Taxol) is the first of a new class of cytotoxic agents with activity against tumors resistant to other drugs. For clinical use, paclitaxel is currently formulated in a vehicle of 50% ethanol and 50% polyethoxylated surfactant Cremophor EL (Cremophor). We have previously sh...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Adult
Aged
Biological Assay
Carrier Proteins
Drug Resistance
Female
Flow Cytometry
Glycerol
Humans
Membrane Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Neoplasm Proteins

Ovarian Neoplasms

Paclitaxel

Pharmaceutical Vehicles

Phenotype

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8105099
DOI: 10.1093/jnci/85.20.1685

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8105099-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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