Article
Measurement of cremophor EL following taxol: plasma levels sufficient to reverse drug exclusion mediated by the multidrug-resistant phenotype.
Journal of the National Cancer Institute - 20 Oct 1993
Webster L, Linsenmeyer M, Millward M, Morton C, Bishop J, Woodcock D
Abstract excerpt
BACKGROUND: Paclitaxel (Taxol) is the first of a new class of cytotoxic agents with activity against tumors resistant to other drugs. For clinical use, paclitaxel is currently formulated in a vehicle of 50% ethanol and 50% polyethoxylated surfactant Cremophor EL (Cremophor). We have previously shown that Cremophor will block the P-glycoprotein drug efflux pump responsible for the multidrug-resistant phenotype....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.