Article
Reversal of multidrug resistance phenotype by surfactants: relationship to membrane lipid fluidity.
Archives of biochemistry and biophysics - 10 May 1995
Dudeja P K, Anderson K M, Harris J S, Buckingham L, Coon J S
Abstract excerpt
Previous studies have suggested that multidrug resistance (MDR) reversal by polyoxyethylene surfactants involves alterations in plasma membrane lipid physical state of resistant cells as one of the possible mechanism(s). To date, however, a detailed and critical examination of the relationship between membrane lipid fluidity and MDR reversal by these surfactants has not been performed. In the present studies,...
Topics
- Cell Line
- Diphenylhexatriene
- Drug Resistance, Multiple
- Flow Cytometry
- Fluorescence Polarization
- Fluorescent Dyes
- Glucosides
- Humans
- Membrane Fluidity
- Membrane Lipids
- Phenotype